Browsing by Author "Sarrigiannis, Ptolemaios Georgios"

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    Brain functional and effective connectivity based on electroencephalography recordings: a review
    (Wiley, 2021-10-20) Cao, Jun; Zhao, Yifan; Shan, Xiaocai; Wei, Hua-Liang; Guo, Yuzhu; Chen, Liangyu; Erkoyuncu, John Ahmet; Sarrigiannis, Ptolemaios Georgios
    Functional connectivity and effective connectivity of the human brain, representing statistical dependence and directed information flow between cortical regions, significantly contribute to the study of the intrinsic brain network and its functional mechanism. Many recent studies on electroencephalography (EEG) have been focusing on modeling and estimating brain connectivity due to increasing evidence that it can help better understand various brain neurological conditions. However, there is a lack of a comprehensive updated review on studies of EEG-based brain connectivity, particularly on visualization options and associated machine learning applications, aiming to translate those techniques into useful clinical tools. This article reviews EEG-based functional and effective connectivity studies undertaken over the last few years, in terms of estimation, visualization, and applications associated with machine learning classifiers. Methods are explored and discussed from various dimensions, such as either linear or nonlinear, parametric or nonparametric, time-based, and frequency-based or time-frequency-based. Then it is followed by a novel review of brain connectivity visualization methods, grouped by Heat Map, data statistics, and Head Map, aiming to explore the variation of connectivity across different brain regions. Finally, the current challenges of related research and a roadmap for future related research are presented.
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    Dementia classification using a graph neural network on imaging of effective brain connectivity
    (Elsevier, 2023-11-18) Cao, Jun; Yang, Lichao; Sarrigiannis, Ptolemaios Georgios; Blackburn, Daniel; Zhao, Yifan
    Alzheimer's disease (AD) and Parkinson's disease (PD) are two of the most common forms of neurodegenerative diseases. The literature suggests that effective brain connectivity (EBC) has the potential to track differences between AD, PD and healthy controls (HC). However, how to effectively use EBC estimations for the research of disease diagnosis remains an open problem. To deal with complex brain networks, graph neural network (GNN) has been increasingly popular in very recent years and the effectiveness of combining EBC and GNN techniques has been unexplored in the field of dementia diagnosis. In this study, a novel directed structure learning GNN (DSL-GNN) was developed and performed on the imaging of EBC estimations and power spectrum density (PSD) features. In comparison to the previous studies on GNN, our proposed approach enhanced the functionality for processing directional information, which builds the basis for more efficiently performing GNN on EBC. Another contribution of this study is the creation of a new framework for applying univariate and multivariate features simultaneously in a classification task. The proposed framework and DSL-GNN are validated in four discrimination tasks and our approach exhibited the best performance, against the existing methods, with the highest accuracy of 94.0% (AD vs. HC), 94.2% (PD vs. HC), 97.4% (AD vs. PD) and 93.0% (AD vs. PD vs. HC). In a word, this research provides a robust analytical framework to deal with complex brain networks containing causal directional information and implies promising potential in the diagnosis of two of the most common neurodegenerative conditions.
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    EEG recordings as biomarkers of pain perception: where do we stand and where to go?
    (Springer, 2022-03-23) Zis, Panagiotis; Liampas, Andreas; Artemiadis, Artemios; Tsalamandris, Gabriela; Neophytou, Panagiota; Unwin, Zoe; Kimiskidis, Vasilios K.; Hadjigeorgiou, Georgios M.; Varrassi, Giustino; Zhao, Yifan; Sarrigiannis, Ptolemaios Georgios
    Introduction: The universality and complexity of pain, which is highly prevalent, yield its significance to both patients and researchers. Developing a non-invasive tool that can objectively measure pain is of the utmost importance for clinical and research purposes. Traditionally electroencephalography (EEG) has been mostly used in epilepsy; however, over the recent years EEG has become an important non-invasive clinical tool that has helped increase our understanding of brain network complexities and for the identification of areas of dysfunction. This review aimed to investigate the role of EEG recordings as potential biomarkers of pain perception. Methods: A systematic search of the PubMed database led to the identification of 938 papers, of which 919 were excluded as a result of not meeting the eligibility criteria, and one article was identified through screening of the reference lists of the 19 eligible studies. Ultimately, 20 papers were included in this systematic review. Results: Changes of the cortical activation have potential, though the described changes are not always consistent. The most consistent finding is the increase in the delta and gamma power activity. Only a limited number of studies have looked into brain networks encoding pain perception. Conclusion: Although no robust EEG biomarkers of pain perception have been identified yet, EEG has potential and future research should be attempted. Designing strong research protocols, controlling for potential risk of biases, as well as investigating brain networks rather than isolated cortical changes will be crucial in this attempt.
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    A revised Hilbert-Huang transformation to track non-stationary association of electroencephalography signals
    (IEEE, 2021-04-28) Shan, Xiaocai; Huo, Shoudong; Yang, Lichao; Cao, Jun; Zou, Jiaru; Chen, Liangyu; Sarrigiannis, Ptolemaios Georgios; Zhao, Yifan
    The time-varying cross-spectrum method has been used to effectively study transient and dynamic brain functional connectivity between non-stationary electroencephalography (EEG) signals. Wavelet-based cross-spectrum is one of the most widely implemented methods, but it is limited by the spectral leakage caused by the finite length of the basic function that impacts the time and frequency resolutions. This paper proposes a new time-frequency brain functional connectivity analysis framework to track the non-stationary association of two EEG signals based on a Revised Hilbert-Huang Transform (RHHT). The framework can estimate the cross-spectrum of decomposed components of EEG, followed by a surrogate significance test. The results of two simulation examples demonstrate that, within a certain statistical confidence level, the proposed framework outperforms the wavelet-based method in terms of accuracy and time-frequency resolution. A case study on classifying epileptic patients and healthy controls using interictal seizure-free EEG data is also presented. The result suggests that the proposed method has the potential to better differentiate these two groups benefiting from the enhanced measure of dynamic time-frequency association.
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    Spatial–temporal graph convolutional network for Alzheimer classification based on brain functional connectivity imaging of electroencephalogram
    (Wiley, 2022-06-25) Shan, Xiaocai; Cao, Jun; Huo, Shoudong; Chen, Liangyu; Sarrigiannis, Ptolemaios Georgios; Zhao, Yifan
    Functional connectivity of the human brain, representing statistical dependence of information flow between cortical regions, significantly contributes to the study of the intrinsic brain network and its functional mechanism. To fully explore its potential in the early diagnosis of Alzheimer's disease (AD) using electroencephalogram (EEG) recordings, this article introduces a novel dynamical spatial–temporal graph convolutional neural network (ST-GCN) for better classification performance. Different from existing studies that are based on either topological brain function characteristics or temporal features of EEG, the proposed ST-GCN considers both the adjacency matrix of functional connectivity from multiple EEG channels and corresponding dynamics of signal EEG channel simultaneously. Different from the traditional graph convolutional neural networks, the proposed ST-GCN makes full use of the constrained spatial topology of functional connectivity and the discriminative dynamic temporal information represented by the 1D convolution. We conducted extensive experiments on the clinical EEG data set of AD patients and Healthy Controls. The results demonstrate that the proposed method achieves better classification performance (92.3%) than the state-of-the-art methods. This approach can not only help diagnose AD but also better understand the effect of normal ageing on brain network characteristics before we can accurately diagnose the condition based on resting-state EEG.
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    Tremor after long term lithium treatment; is it cortical myoclonus?
    (BMC (part of Springer Nature), 2019-05-22) Sarrigiannis, Ptolemaios Georgios; Zis, Panagiotis; Unwin, Zoe Charlotte; Blackburn, Daniel J.; Hoggard, Nigel; Zhao, Yifan; Billings, Stephen A.; Khan, Aijaz A.; Yianni, John; Hadjivassiliou, Marios
    Introduction: Tremor is a common side effect of treatment with lithium. Its characteristics can vary and when less rhythmical, distinction from myoclonus can be difficult. Methods: We identified 8 patients on long-term treatment with lithium that developed upper limb tremor. All patients were assessed clinically and electrophysiologically, with jerk-locked averaging (JLA) and cross-correlation (CC) analysis, and five of them underwent brain MRI examination including spectroscopy (MRS) of the cerebellum. Results: Seven patients (6 female) had action and postural myoclonus and one a regular postural and kinetic tremor that persisted at rest. Mean age at presentation was 58 years (range 42–77) after lengthy exposure to lithium (range 7–40 years). During routine monitoring all patients had lithium levels within the recommended therapeutic range (0.4-1 mmol/l). There was clinical and/or radiological evidence (on cerebellar MRS) of cerebellar dysfunction in 6 patients. JLA and/or CC suggested a cortical generator of the myoclonus in seven patients. All seven were on antidepressants and three additionally on neuroleptics, four of them had gluten sensitivity and two reported alcohol abuse. Conclusions: A synergistic effect of different factors appears to be contributing to the development of cortical myoclonus after chronic exposure to lithium. We hypothesise that the cerebellum is involved in the generation of cortical myoclonus in these cases and factors aetiologically linked to cerebellar pathology like gluten sensitivity and alcohol abuse may play a role in the development of myoclonus. Despite the very limited evidence in the literature, lithium induced cortical myoclonus may not be so rare.