Browsing by Author "Rebrov, Evgeny"
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Item Open Access Characterising flow with continuous aeration in an oscillatory baffle flow reactor using residence time distribution(Royal Society of Chemistry, 2023-08-30) Cox, Rylan; Salonitis, Konstantinos; Impey, Susan A.; Rebrov, EvgenyMulti-phase flow occurs in many reactions with gas, an integral part of the reaction. This study assesses the synergistic impact of continuous aeration and velocity ratio on mixing conditions within an oscillatory baffled flow reactor to enhance the degree of plug flow, quantified by a tanks-in-series (TiS) model. A bubbly flow regime is shown in all experiments. In most cases, the TiS value was reduced with gas flow, and a maximum TiS value of 23.6 was achieved at a velocity ratio of 3.8 at 225 ml min−1 in a counter-current direction. Single-phase runs and co-current multi-phase runs produced maximum TiS values of 23.5 and 18.2 respectively at a velocity ratio of 2.2. Regardless of the gas flow rate, the velocity ratio was found to be the most influential factor that dictates the level of plug flow within the OBR. A predictive model is developed and used to maximise the mixing efficiency by determining the level of plug flow within the OBR at selected amplitudes, frequencies, and gas flow rates.Item Open Access Revisiting the effect of U-bends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor(American Chemical Society, 2022-07-18) Cox, Rylan; Salonitis, Konstantinos; Rebrov, Evgeny; Impey, Susan A.Abstract An oscillatory baffled flow reactor (OBR) has been designed with 60 interbaffled cells. The baffled columns of 40 mm internal diameter together result in a reactor length of 5740 mm. The oscillatory amplitude and frequency were in the range of 2–12 mm and 0.3–2 Hz, respectively. The report investigates the impact of U-bends and the number of reactor sections on axial dispersion for scale-up feasibility. A prediction model using operating parameters has been developed to maximize plug flow conditions using the tanks-in-series (TiS) model. The maximum TiS value was 13.38 in a single column compared to 43.68 in the full reactor at a velocity ratio of 2.27 using oscillatory parameters 8 mm and 0.3 Hz. The mixing efficiency along the reactor was found to decrease after each column at amplitudes <6 mm compared to amplitudes up to 12 mm, where a negligible impact was observed. U-bend geometry had a significant role in the decrease of TiS values.