Browsing by Author "Mohammadinejad, Reza"
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Item Open Access Chitosan-based advanced materials for docetaxel and paclitaxel delivery: Recent advances and future directions in cancer theranostics(Elsevier, 2019-12-20) Ashrafizadeh, Milad; Ahmadi, Zahra; Mohamadi, Neda; Zarrabi, Ali; Abasi, Sara; Dehghannoudeh, Gholamreza; Tamaddondoust, Rosette N.; Khanbabaei, Hashem; Mohammadinejad, Reza; Thakur, Vijay KumarPaclitaxel (PTX) and docetaxel (DTX) are key members of taxanes with high anti-tumor activity against various cancer cells. These chemotherapeutic agents suffer from a number of drawbacks and it seems that low solubility in water is the most important one. Although much effort has been made in improving the bioavailability of PTX and DTX, the low bioavailability and minimal accumulation at tumor sites are still the challenges faced in PTX and DTX therapy. As a consequence, bio-based nanoparticles (NPs) have attracted much attention due to unique properties. Among them, chitosan (CS) is of interest due to its great biocompatibility. CS is a positively charged polysaccharide with the capability of interaction with negatively charged biomolecules. Besides, it can be processed into the sheet, micro/nano-particles, scaffold, and is dissolvable in mildly acidic pH similar to the pH of the tumor microenvironment. Keeping in mind the different applications of CS in the preparation of nanocarriers for delivery of PTX and DTX, in the present review, we demonstrate that how CS functionalized-nanocarriers and CS modification can be beneficial in enhancing the bioavailability of PTX and DTX, targeted delivery at tumor site, image-guided delivery and co-delivery with other anti-tumor drugs or genes.Item Open Access Multifunctional polymeric nanoplatforms for brain diseases diagnosis, therapy and theranostics(MDPI, 2020-01-13) Shakeri, Shahryar; Ashrafizadeh, Milad; Zarrabi, Ali; Roghanian, Rasoul; Afshar, Elham Ghasemipour; Pardakhty, Abbas; Mohammadinejad, Reza; Kumar, Anuj; Thakur, Vijay KumarThe blood–brain barrier (BBB) acts as a barrier to prevent the central nervous system (CNS) from damage by substances that originate from the blood circulation. The BBB limits drug penetration into the brain and is one of the major clinical obstacles to the treatment of CNS diseases. Nanotechnology-based delivery systems have been tested for overcoming this barrier and releasing related drugs into the brain matrix. In this review, nanoparticles (NPs) from simple to developed delivery systems are discussed for the delivery of a drug to the brain. This review particularly focuses on polymeric nanomaterials that have been used for CNS treatment. Polymeric NPs such as polylactide (PLA), poly (D, L-lactide-co-glycolide) (PLGA), poly (ε-caprolactone) (PCL), poly (alkyl cyanoacrylate) (PACA), human serum albumin (HSA), gelatin, and chitosan are discussed in detail.Item Open Access Status and future scope of plant-based green hydrogels in biomedical engineering(Elsevier, 2019-06-12) Mohammadinejad, Reza; Maleki, Hajar; Larrañeta, Eneko; Fajardo, André R.; Bakhshian Nik, Amirala; Shavandi, Amin; Sheikhi, Amir; Ghorbanpour, Mansour; Farokhi, Mehdi; Govindh, Praveen; Cabane, Etienne; Azizi, Susan; Reza Aref, Amir; Mozafari, Masoud; Mehrali, Mehdi; Thomas, Sabu; Mano, João F.; Mishra, Yogendra Kumar; Thakur, Vijay KumarHydrogels are the most iconic class of soft materials, and since their first report in the literature, they have attracted the attention of uncountable researchers. Over the past two decades, hydrogels have become smart and sophisticated materials with numerous applications. This class of soft materials have been playing a significant role in biomedicine due to their tunable and often programmable properties. Hydrogels from renewable polymers have been popularized in biomedical applications as they are often biocompatible, easily accessible, and inexpensive. The challenge however has been to find an ideal plant-based hydrogel for biomedicine that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, natural polymers can readily be functionalized to engineer their chemical and physical uproperties pertinent to drug delivery and tissue engineering. Here, the most recent advances in the synthesis, fabrication, and applications of plant-based hydrogels in biomedical engineering are reviewed. We cover essential and updated information about plants as green sources of biopolymers for hydrogel synthesis, general aspects of hydrogels and plant-based hydrogels, and thorough discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review details the present status of the field and answers several important questions about the potential of plant-based hydrogels in advanced biomedical applications including therapeutics, tissue engineering, wound dressing, and diagnostics.