Browsing by Author "Alves-Cardoso, Francisca"
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Item Open Access Metagenomic research of infectious diseases in archaeological contexts: evidence from the Hospital Real de Todos-os-Santos (Portugal)(MDPI, 2022-06-15) Alves-Cardoso, Francisca; Palomo-Díez, Sara; Alonso Conde, Alejandro; Gomes, Cláudia; Casimiro, Silvia; Banha da Silva, Rodrigo; Arroyo-Pardo, EduardoSyphilis is one of the most exciting diseases explored in paleopathology and, therefore, tracing back its origin and development has provided a prolific debate. The combination of paleopathological data with historical sources, iconography, and archaeological contexts were the primary sources used to reconstruct its historical path. However, there are some limitations to paleopathological diagnosis due to the nature of bone reaction to stimuli. In addition, historical sources are subjected to a bias of social and cultural nature and the knowledge of those who wrote them. Hence, ancient DNA analysis offers the possibility of acquiring proof of cause by identifying pathogens in an organism. We undertook a metagenomic study of a skeleton exhumed from the Royal Hospital of All Saints (Portugal), renowned for treating syphilis from the 16th century onwards. The skeleton had previously been diagnosed with syphilis according to paleopathological analysis. However, the metagenomics analysis showed no presence of the pathogen associated with syphilis (i.e., Treponema pallidum) but revealed pathogenic microorganisms related to respiratory diseases (pneumonia), nonspecific bone infections (osteomyelitis), and oral bacterial pathologies as well as Hansen’s disease (also known as leprosy). The results are exciting and demand a reappraisal of the observed bone changes, recontextualizing their characterization as syphilis related. They prove that past reconstruction of health and disease diagnoses based on assessing human osteological remains of known context (such as a syphilitic hospital) may bias interpretations and, therefore, caution is recommended, not forgetting that the absence of evidence is not evidence of absence (in this case of syphilis) in life.Item Open Access To replicate, or not to replicate? the creation, use, and dissemination of 3D models of human remains: a case study from Portugal(MDPI, 2022-07-08) Alves-Cardoso, Francisca; Campanacho, VanessaAdvancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely distributed online. However, ethical considerations about such 3D models have not reached Portuguese society, making it impossible to assess their societal impact and people’s perception of how these models are created and used. Therefore, Portuguese residents were asked to take part in an online survey. The ratio of male to female participants was 0.5:1 in 312 contributors. The age ranged between 18 and 69 years. The majority had a higher education degree. Only 43% had seen a 3D model, and 43% considered the 3D replicas the same as real bone. Also, 87% would be willing to allow their skeleton and family members to be digitalized after death, and 64% advocated the controlled dissemination of replicas through registration and login and context description association (84%). Overall, the results suggest agreement in disseminating 3D digital replicas of human bones. On a final note, the limited number of participants may be interpreted as a lack of interest in the topic or, more importantly, a low self-assessment of their opinion on the subject.