dc.contributor.advisor |
Piletsky, Sergey A. |
|
dc.contributor.advisor |
Turner, Anthony P. F. |
|
dc.contributor.author |
Biela, Anna |
|
dc.date.accessioned |
2011-10-03T08:54:17Z |
|
dc.date.available |
2011-10-03T08:54:17Z |
|
dc.date.issued |
2010-07 |
|
dc.identifier.uri |
http://dspace.lib.cranfield.ac.uk/handle/1826/6275 |
|
dc.description.abstract |
Diabetes mellitus is a growing health problem worldwide. Suitable long-term control
and management of this disease are enabled by determination of glycated haemoglobin
(HbA1c) in blood. The results are given as %HbA1c of total haemoglobin. Presently
available tests vary in cost and convenience and there is an identified need to introduce
improved equipment for self-monitoring. This dissertation focuses on fast and
straightforward detection of glycated haemoglobin (HbA1c) using cyclic voltammetry
and chronoamperometry. Haemoglobin was determined by monitoring its reaction with
potassium ferricyanide on screen printed electrodes at an oxidative potential +500 mV.
A working electrode was modified with carbon nanotubes to enhance electron transfer.
A calibration curve was linear in a range from 0.83 to 83 mg/mL. Another innovative
approach to detecting haemoglobin using its enzymatic activity was also developed.
Detection of haemoglobin was performed with hydroquinone and hydrogen peroxide on
screen printed electrodes at a potential -400 mV in a Flow Injection Analysis system
(FIA). Cont/d. |
en_UK |
dc.language.iso |
en |
en_UK |
dc.publisher |
Cranfield University |
en_UK |
dc.rights |
© Cranfield University, 2010. All rights reserved. No part of this publication may be
reproduced without the written permission of the copyright owner |
en_UK |
dc.title |
Biomimetic sensors for HbA1c |
en_UK |
dc.type |
Thesis or dissertation |
en_UK |
dc.type.qualificationlevel |
Doctoral |
en_UK |
dc.type.qualificationname |
PhD |
en_UK |