dc.contributor.author |
Knobloch, Henri |
|
dc.contributor.author |
Schroedl, Wieland |
|
dc.contributor.author |
Turner, Claire |
|
dc.contributor.author |
Chambers, Mark |
|
dc.contributor.author |
Reinhold, Petra |
|
dc.date.accessioned |
2010-01-23T11:38:39Z |
|
dc.date.available |
2010-01-23T11:38:39Z |
|
dc.date.issued |
2010-01 |
|
dc.identifier.citation |
Henri Knobloch, Wieland Schroedl, Claire Turner, Mark Chambers, Petra Reinhold, Electronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infection, Sensors and Actuators B: Chemical, Volume 144, Issue 1, 29 January 2010, Pages 81-87 |
en_UK |
dc.identifier.issn |
0925-4005 |
|
dc.identifier.uri |
http://dx.doi.org/10.1016/j.snb.2009.10.034. |
|
dc.identifier.uri |
http://hdl.handle.net/1826/4178 |
|
dc.description.abstract |
This study aimed (i) to assess the ability of electronic nose (e-nose) technology to differentiate
between blood samples of experimentally infected and non-infected subjects, and (ii) to evaluate
e-nose responses given by volatile organic compounds in relation to the acute phase reaction
generated in the host. In an animal model of gram-negative bacterial infection (20 calves;
intratracheal inoculation of Mannheimia haemolytica A1), the concentrations of the acute phase
proteins (APPs; i.e. lipopolysaccharide binding protein and haptoglobin) were measured in serum
samples before and after challenge, and headspaces of pre- and post-inoculation serum samples
were analysed using a conducting polymer based e-nose. Significant changes of certain e-nose
sensor responses allowed discrimination between samples before and after challenge. The
maximal changes in responses of sensitive e-nose sensors corresponded to the peak of clinical
signs. Significant correlations linked decreasing responses of multiple e-nose sensors to
increasing concentrations of APPs in the peripheral blood. |
en_UK |
dc.language.iso |
en |
en_UK |
dc.publisher |
Elsevier |
en_UK |
dc.subject |
electronic nose |
en_UK |
dc.subject |
acute phase proteins (APP), |
en_UK |
dc.subject |
animal model |
en_UK |
dc.subject |
gram-negative bacterial |
en_UK |
dc.subject |
Mannheimia haemolytica A1 |
en_UK |
dc.subject |
host response |
en_UK |
dc.title |
Electronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infection |
en_UK |
dc.type |
Article |
en_UK |