The use of μCT and fractal dimension for fracture prediction in osteoporotic individuals

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dc.contributor.author Arnold, Emily L.
dc.contributor.author Clement, John
dc.contributor.author Rogers, Keith D.
dc.contributor.author Garcia-Castro, Fabio
dc.contributor.author Greenwood, Charlene
dc.date.accessioned 2020-01-17T14:38:08Z
dc.date.available 2020-01-17T14:38:08Z
dc.date.issued 2019-12-11
dc.identifier.citation Arnold EL, Clement J, Rogers KD, et al., The use of μCT and fractal dimension for fracture prediction in osteoporotic individuals. Journal of the Mechanical Behavior of Biomedical Materials, Volume 103, March 2020, Article number 103585 en_UK
dc.identifier.issn 1751-6161
dc.identifier.uri https://doi.org/10.1016/j.jmbbm.2019.103585
dc.identifier.uri http://dspace.lib.cranfield.ac.uk/handle/1826/14946
dc.description.abstract Osteoporosis (OP) is a widespread condition with commonly associated fracture sites at the hip, vertebra and wrist. This study examines the effects of age and osteoporosis on bone quality by comparing the efficacy of using parameters which indicate bone quality (both traditional clinical parameters such as bone mineral density (BMD), as well as apparent Young's modulus determined by finite element analysis, among others) to predict fracture. Non-fracture samples were collected from the femoral heads of 83 donors (44 males, 39 females), and fracture samples were obtained from the femoral heads of 17 donors (female). Microarchitectural parameters (Bone Volume/Total Volume [BV/TV], Bone Surface/Bone Volume [BS/BV], Tissue Mineral Density [TMD, etc.]) were measured from μCT of each sample as well as 2D and 3D fractal dimension (D2D and D3D respectively). A cube was cropped from μCT images and an isotropic hexahedral element was assigned to each voxel. Finite element analysis was used to calculate the Young's modulus for each sample. Overall, values for microarchitectural characteristics, fractal dimension measurements and Young's Modulus were consistent with values within literature. Significant correlations are observed between age and BV/TV for non-fracture males and females, as well as between age and volumetric BMD (vBMD) for the same groups. Significant differences are present between age-matched non-fracture and fracture females for BV/TV, BS/BV, vBMD, TMD, D2D, D3D, (p < 0.01 for all). Properties which are not age dependent are significantly different between age-matched non-fracture and fracture specimens, indicating OP is a disease, and not just an accelerated aging process. en_UK
dc.language.iso en en_UK
dc.publisher Elsevier en_UK
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 International *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.subject Bone μCT en_UK
dc.subject Osteoporosis en_UK
dc.subject Femoral head en_UK
dc.subject Finite element analysis en_UK
dc.subject Fractal dimension en_UK
dc.title The use of μCT and fractal dimension for fracture prediction in osteoporotic individuals en_UK
dc.type Article en_UK


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