Browsing by Author "Cullen, David C."

CASS•E: Cranfield astrobiological stratospheric sampling experiment

Naicker, L.; Grama, V. V.; Juanes-Vallejo, Clara M.; Katramados, Ioannis; Rato, Carla Cristina Pereira Salgueiro Catarino; Rix, Catherine S.; Sanchez, E.; Cullen, David C. (2010-12-31)

CASS•E is a life detectionexperimentthat aims to be capable of collecting microorganisms in Earth's Stratosphere. Theexperiment will be launched on astratosphericballoon in collaboration with Eurolaunch through the ...

Correlations between life-detection techniques and implications for sampling site selection in planetary analog missions

Gentry, Diana M.; Amador, Elena S.; Cable, Morgan L.; Chaudry, Nosheen; Cullen, Thomas; Jacobsen, Malene B.; Murukesan, Gayathri; Schwieterman, Edward W.; Stevens, Adam H.; Stockton, Amanda; Tan, George; Yin, Chang; Cullen, David C.; Geppert, Wolf (Mary Ann Liebert, Inc., 2017-10-01)

We conducted an analog sampling expedition under simulated mission constraints to areas dominated by basaltic tephra of the Eldfell and Fimmvörðuháls lava fields (Iceland). Sites were selected to be “homogeneous” at a ...

CubeSat 3U-payload for in-situ resource utilisation demonstration at C-type near Earth asteroids

Elioenai, Sitepu; Cullen, David C. (IAF, 2018-10-05)

payloads capable of performing cost effective early stage in situ demonstrations of key steps for various types of ISRU. Such demonstrations would be proof-of-concept and de-risking exercises that would enable future pilot ...

Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction

Al Qaraghuli, Mohammed M.; Palliyil, Soumya; Broadbent, Gillian; Cullen, David C.; Charlton, Keith A.; Porter, Andrew J. (BMC (part of Springer Nature), 2015-10-24)

Background: Low molecular weight haptens (<1000 Da) cannot be recognized by the immune system unless conjugated to larger carrier molecules. Antibodies to these exceptionally small antigens can still be generated with ...

Demonstration of a multi-technique approach to assess glacial microbial populations in the field

Barnett, Megan J.; Pawlett, Mark; Wadham, Jemma L.; Jackson, Miriam; Cullen, David C. (Cambridge University Press, 2016-04-04)

The ability to perform microbial detection and characterization in-field at extreme environments, rather than on returned samples, has the potential to improve the efficiency, relevance and quantity of data from field ...

The design of beyond LEO mission scenario for a biological payload with a cubesat.

Pratnekar, Marko (2019-06)

CubeSat technology has been well established in the area of space engineering for almost two decades. Because of standardisation of components and procedures, development and launch costs of space missions are greatly reduced ...

Detecting life on Mars and the life marker chip : antibody assays for detecting organic molecules in liquid extracts of Martian samples

Rix, Catherine S. (Cranfield University, 2012-01)

The Life Marker Chip instrument, which has been selected to fly as part of the 2018 ExoMars rover mission payload, aims to detect up to 25 organic molecules in martian rocks and regolith, as markers of extant life, extinct ...

Development of a fluidic sensor for the detection of herbicides using thylakoid preparations immobilised on magnetic beads to aid regenerability

Varsamis, Dimitrios Georgios (Cranfield University, 2008-12)

Following the industrial revolution and advances in chemical science, the pollution of the environment with trace organic pollutants has been steadily increasing, which is of concern, due to their effect on the environmental ...

Development of an automated identification system for nanocrystal encoded microspheres in flow cytometry

Gallagher, Clair (Cranfield University, 2009-04)

Aim: This work sets out to use haplotype-based tagSNP selection and a systematic in silico analysis for design of multiplex-compatible PCR primer and SAT probe sets to capture maximum variation with minimum tests across ...

Development of antibodies for life-detection experiment in extreme environments; implications for astrobiology

Derveni, Maria Elisavet (Cranfield University, 2010-11)

The Life Marker Chip (LMC) instrument is an antibody assay-based system which will attempt to detect molecular signatures of Life in the Martian subsurface as part of the payload on board the European Space Agency (ESA) ...

Development of life marker chip technology for in-situ life detection on Mars

Wilson, P. K. (Cranfield University, 2007-04)

The European Space Agency (ESA) is currently developing its flagship Life Detection Mission, ExoMars, which is scheduled to fly to Mars in 2013. The primary goal of this mission is to compliment the Phoenix NASA mission ...

Engineering design instrumentation for life detection planetary exploration missions

Juanes-Vallejo, Clara M. (Cranfield University, 2011-10)

The aim of the research documented in this thesis was to explore issues associated with the development of instrumentation for life detection and characterisation in a planetary exploration context. Within this aim, the ...

Extraction of polar and nonpolar biomarkers from the martian soil using aqueous surfactant solutions

Court, Richard W.; Rix, Catherine S.; Sims, Mark R.; Cullen, David C.; Sephton, Mark A. (Elsevier Science B.V., Amsterdam., 2012-12-31)

The Life Marker Chip intends to use an aqueous surfactant solution to extract both polar AND nonpolar biomarkers from the martian soil for transport to an antibody-based detection system. Currently, a solution of 1.5 g ...

Granular sample collection simulation via counter rotating wheels sampler for small-sized system at reduced gravity environment

Sitepu, Elioenai; Cullen, David C. (Elsevier, 2023-09-13)

The launching and planning of space missions for asteroid exploration have increased due to their scientific interest and potential resources for future use, such as composition analysis and In-Situ Resource Utilization ...

High frequency thin-film bulk acoustic wave resonators for gas- and bio-analytical applications

Ashley, Greg M. (2000-10)

Thin Film Bulk Acoustic Wave Resonators (FBAR) are mechanical micro scale devices that operate in the UHF/Microwave frequency range. This high frequency of operation potentially offers increased sensitivity to the addition ...

Immunological detection of small organic molecules in the presence of perchlorates: relevance to the life marker chip and life detection on Mars.

Rix, Catherine S.; Sims, Mark R.; Cullen, David C. (Mary Ann Leibert, 2011-11-17)

The proposed ExoMars mission, due to launch in 2018, aims to look for evidence of extant and extinct life in martian rocks and regolith. Previous attempts to detect organic molecules of biological or abiotic origin on ...

Implementation of in-field life detection and characterisation techniques in icy environments

Barnett, Megan (Cranfield University, 2010-06)

An emerging trend towards non-laboratory based biological and microbiological marker analysis is occurring in multiple sectors of science and industry. In the medical sector, these trends have demonstrated that conducting ...

Investigation of denugue virus envelope gene quasispecies variation in patient samples : implications for virus virulence and disease pathognesis

Love, Hannah (Cranfield University, 2011-09)

Due to the error-prone nature of RNA virus replication, each dengue virus (DV) exists as a quasispecies within the host. To investigate the hypothesis that DV quasispecies populations affect disease severity, serum samples ...

Investigation of the effect of structured hyaluronic acid surfaces on cell proliferation and expression of HA cellular receptors:CD44 and RHAMM

Marques, Ana Catia Ferrao (Cranfield University, 2011-03)

Hyaluronic acid (HA) is one of the major components of the extracellular matrix; and may exhibit different biological functions, dependent on polymer molecular weight (MW). The signalling events performed by HA are mediated ...

The life marker chip : potential use of aptamers against small molecules and consideration of instrument planetary protection

Rato, Carla Cristina Pereira Salgueiro Catarino (Cranfield University, 2013-05)

The Life Marker Chip (LMC) instrument was developed with the aim to detect evidence of life on Mars. The detection was based on an inhibition immunoassay. In this work aptamers were evaluated as potential alternative to ...

Browsing by Author "Cullen, David C."

Browsing by Author "Cullen, David C."

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